Biochemical Mechanism of Kanamycin Resistance inMycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.
An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and low...
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A strain of Proteus vulgaris isolated from the urinary tract of a patient with postoperative pyelonephritis and resistant to sulfonamide, streptomycin, tetracycline, and kanamycin (KM) was found to transfer only KM resistance by cell-to-cell conjugation. The genetic determinant controlling the transferable KM resistance was considered to be an R factor and was designated R (KM). Successive tran...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 1977
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.1977.tb00294.x